ENICTO Cross-Consortium Collaborative Pilots

To foster novel ideas and collaboration, ENICTO investigators are able to apply for $175,000 each year to conduct Cross-Consortium Collaborative Pilots. This pilots help inform the feasibility and translation of cancer treatment approaches into clinical care.

Year 3 (2024-2025)

Projects approved by the Steering Committee in June 2023 for funding from July 1, 2024 - June 30, 2025.

Additional Support Systems in Study Technology (ASSIST)

Aim: Develop a system to monitor patient barriers and facilitators (including patient-provider communication) for digital health device implementation

Led by: Jessica Scott and Jenna Harrison
Projects involved: TNT, TEAL, THRIVE-65,
Coordinating, and NCI

Exploring Barriers and Facilitators of Adopting Health Behaviors

Aim: Conduct qualitative assessments to record the barriers and facilitators of engagement and adherence to ENICTO guideline-based lifestyle recommendations delivered during chemotherapy.

Led by: Leah Puklin
Projects involved: TEAL, ACTION, THRIVE-65, TNT, and Coordinating Center

Implementation Science in ENICTO (2nd year)

Aim: Identify and specify the core functions of the ENICTO programs and develop a process to document adaptations. It also aims to assess satisfaction among patients.

Led by: Karen Basen-Engquist
Projects involved: ACTION, TEAL, THRIVE-65, TNT, Coordinating Center, and NCI

Microbiome Pilot Study

Aim: Collect and archive stool samples at baseline and end of intervention from participants and collect preliminary data on the acceptability and feasibility of stool sample collection.

Led by: Bette Caan, Kim Robien
Projects involved: Coordinating Center, ACTION, TEAL, TNT, NCI, and Harvard Consultant

Preventing Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Aim: Assess the effect of a diet and/or exercise intervention on prevention of CIPN during chemotherapy in cancer patients via objective assessments of CIPN (SWME and tuning fork measurement of vibration).

Led by: Christina Dieli-Conwright, Leah Ferrucci
Projects involved: ACTION, TEAL,
THRIVE-65, Coordinating Center, and NCI

Relationship between historical physical activity and cancer treatment outcomes

Aim: Better understand the role of cumulative lifetime and age-specific physical activity in cancer treatment outcomes

Led by: Loretta DiPietro
Projects involved: Coordinating Center, ACTION, TEAL, THRIVE-65, TNT, and NCI

Year 2 (2024-2025)

Projects approved by the Steering Committee in June 2023 for funding from July 1, 2023 - June 30, 2024.

Hand-Grip Strength (HGS)

Aim: To add HGS to study sites not currently including a strength as a measure.

Led by: Helena Furberg-Barnes
Projects involved: ACTION, TNT

Exercise Adherence

Aim: To develop an integrated tool to quantify unsupervised prescribed and completed exercise sessions.

Led by: Jenna Harrison
Projects involved: TNT

CGM & Glycemic Control

Aim: To determine the feasibility, acceptability, and data quality of continuous glucose monitoring in a population of colon cancer survivors before and after receiving chemotherapy.

Led by: Stephanie Compton
Projects involved: ACTION

Monitor-Independent Movement Summary (MIMS) Unit Methodology

Aim: To develop the research infrastructure and programming codes for transforming Withings Scanwatch-specific physical activity data into MIMS units.

Led by: Loretta DiPietro
Projects involved: ACTION, TNT, Coordinating Center, NCI

Implementation Science

Aim: Identify and specify the core functions of the ENICTO programs and develop a process to document adaptations. It also aims to assess satisfaction among patients.

Led by: Karen Basen-Engquist, Borsika Rabin
Projects involved: TEAL, ACTION, TNT, THRIVE-65, Coordinating Center, NCI

Patient Information Sources

Aim: Determine prevalent nutrition- and exercise-related topics of interest among patients newly diagnosed with cancer receiving chemotherapy and if topics led to exercise-related behavior change.

Led by: Courtney McGowan
Projects involved: TEAL, ACTION, TNT, THRIVE-65, Coordinating Cetner